The main features of the program are: 1) Intuitive and versatile interactive interface 2) Absolute and semi-logarithmic graphical output 3) Pre-programmed optimized human parameter data set (but, arbitrary values can be input) 4) Time dependent changes in the PBPK parameters 5) Non-linear parameter optimization 6) Unique approach to determine the oral "first pass metabolism" of non-linear solutes (e.g. The complete PBPK description for each solute is stored in Excel spreadsheets that are included in the download. Included in the download is a detailed tutorial that discusses the pharmacokinetics of 6 solutes (D 2O, amoxicillin, desflurane, propofol, ethanol and thiopental) illustrated using experimental human pharmacokinetic data. The program is written in Java and is available for free download at. Currently there are no software packages available that combine ease of use with the versatility that is required of a general PBPK program. PBPK applications require both sophisticated mathematical modeling software and a reliable complete set of physiological parameters. The blood-tissue exchange of each organ is characterized by its volume, perfusion, metabolism, capillary permeability and blood/tissue partition coefficient. Physiologically based pharmacokinetics (PBPK) uses a realistic organ model to describe drug kinetics.
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